Naked Lunch

Naked Lunch is a movie starring Peter Weller, Judy Davis, and Ian Holm. After developing an addiction to the substance he uses to kill bugs, an exterminator accidentally kills his wife, and becomes involved in a secret government...
Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.