Mousehunt

Mousehunt is a movie starring Nathan Lane, Lee Evans, and Vicki Lewis. Two stumblebum inheritors are determined to rid their antique house of a mouse who is equally determined to stay where he is.
Down-on-their luck brothers, Lars and Ernie Smuntz, aren't happy with the crumbling old mansion they inherit... until they discover the estate is worth millions. Before they can cash in, they have to rid the house of its single, stubborn occupant—a tiny and tenacious mouse.