Rubber

Rubber is a movie starring Stephen Spinella, Roxane Mesquida, and Wings Hauser. A homicidal car tire, discovering it has destructive psionic power, sets its sights on a desert town once a mysterious woman becomes its obsession.
A group of people gather in the California desert to watch a "film" set in the late 1990s featuring a sentient, homicidal car tire named Robert. The assembled crowd of onlookers watch as Robert becomes obsessed with a beautiful and mysterious woman and goes on a rampage through a desert town.